Applications are invited for a 12‑month Postdoctoral Research Associate position funded by the Medical Research Council. This is an exciting opportunity to be a researcher in an interdisciplinary project entitled “Developing PROTACs for the Target Validation of Individual Histone Deacetylase Corepressor Complexes.” This is a collaborative project between the groups of Dr James Hodgkinson (School of Chemistry and Leicester Institute of Structural and Chemical Biology, LISCB), Professor John Schwabe (Department of Molecular and Cell Biology and LISCB) and Professor Shaun Cowley (Department of Molecular and Cell Biology).
In this role your primary responsibility will be implementing the organic synthesis and biological evaluation of novel proteolysis-targeting chimera (PROTAC) libraries for the targeted degradation of Histone Deacetylase (HDAC) enzymes and associated corepressor complexes. Candidates must have hands‑on experience in the organic synthesis of HDAC‑targeting PROTACs, molecular and cell biology methodologies for their evaluation, including expression of class I HDAC complexes from mammalian cell culture, and quantitative proteomics. The successful candidate will also contribute high‑level research skills in chemical biology through personal expertise and by supporting the wider research team, and will take a leading role in the presentation of results and manuscript/IP preparation.
The Leicester Institute of Structural and Chemical Biology (LISCB) is a cross-disciplinary entity that brings together internationally renowned research in structural biology and chemical biology at the University of Leicester into a single world‑leading unit. The Institute aims to exploit synergies in research technologies to deliver major advances in both fundamental and translational research.