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About the role
We have an exciting opportunity for highly motivated postdoctoral candidates to lead a new project, which tackles fundamental questions in regulation of gene expression through chromatin modification. The post of Research Associate is funded by the BBSRC to investigate the role of H2B ubiquitylation in heterochromatin formation and its mechanism in the promotion of euchromatic domains. The successful candidate will join a vibrant community at the University of Leicester’s Department of Molecular and Cell Biology and will be based in the research group of Dr. Thomas Schalch, which has a long-standing interest in structural and functional understanding of chromatin and its impact on gene expression. The Research Associate will be a member of the Leicester Institute for Structural and Chemical Biology (LISCB), a centre of research excellence initiated by the University of Leicester, which provides access to state-of-the-art integrated structural approaches comprising cryo-electron microscopy, X-ray crystallography and biomolecular nuclear magnetic resonance (NMR). LISCB hosts a Titan Krios G3, 600 and 800 MHz Bruker NMR spectrometers with cryo-probes, a Rigaku X-ray diffraction system, multiple robotic systems for preparing crystal screens, excellent computer facilities and a range of HPLC and FPLC protein chromatography systems. Dedicated computing facilities and senior cryo-EM and computational experimental officers support the project.
 
Primary Supervisor: Dr Thomas Schalch, University of Leicester, UK
Collaborator: Professor Marc Bühler, Freidrich Miescher Institute Basel, Switzerland 
 
About you

The ideal candidate will have a PhD in molecular biology, experience in protein expression and purification, biochemical characterization and knowledge of X-ray or cryo-EM structural analysis. A high level of proficiency in English and excellent written and verbal communication skills are essential requirements for this position.

Please refer to the job summary on the right hand side for further information about the specific requirements of the role.
Additional information
Informal enquiries are welcome and should be made to Dr Thomas Schalch on thomas.schalch@leicester.ac.uk.
 
Leicester is a leading University committed to international excellence, world-changing research and high quality, inspirational teaching. We are strongly committed to inclusivity, promoting equality and celebrating diversity among our staff and students. You will develop your career in a supportive and collaborative academic environment in one of the world’s leading research-intensive universities; elite in the excellence of our research, yet distinctive for the genuine synergy between our research and teaching.
 
In return for your hard work, we offer a working environment that is committed to inclusivity, through promoting equality and valuing diversity. We offer a competitive salary package with excellent pension scheme and a generous annual leave allowance. Located close to Leicester city centre, our award winning campus benefits from a wide range of cafes, a fully equipped sports centre and nursery facilities. Further information regarding our extensive range of staff benefits is available here.