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About the role

We are seeking to appoint a Research Technician to provide support to the research goals of a multi-disciplinary BBSRC-funded sLOLA grant entitled, ‘How do RNA-binding proteins control splice site selection?’. This will involve support work and conducting experiments, using a range of techniques, under the guidance of the Principal Investigator and the executive board of the consortium.

One of the biggest challenges in molecular biology is presented by the selection of sites for RNA splicing. We cannot overstate its importance or apparent complexity. We have recently developed a multi-disciplinary approach based on single molecule methods and chemical biology that will enable us to meet this challenge. This £4m grant brings together experts in RNA splicing, single molecule spectroscopy, chemical biology, structural biology and nano-patterning of surfaces and will support 7 postdoctoral researchers (4 in Leicester, 2 in Strathclyde and 1 in Glasgow) who will use and develop methods involving single molecule colocalization, FRET and scattering, chemical synthesis, NMR, molecular biology and novel surface modifications.

The University of Leicester provides an excellent environment for this research. The three groups in Leicester belong to the Leicester Institute for Structural and Chemical Biology (LISCB), which is a centre of research excellence initiated by the University of Leicester. The three groups are housed in a single modern and well-appointed research building.  We have several home-built single molecule microscopes, and new instruments are being acquired and modified as part of the programme. The Institute has 600 and 800 MHz Bruker NMR spectrometers with cryo-probes, and we will be acquiring an HR-MAS probe for this project. In addition, there is a Titan Krios G3 cryo-EM, a Rigaku X-ray diffraction system, multiple robotic systems for preparing crystal screens, excellent computer facilities and a range of HPLC and FPLC protein chromatography systems. 

About you
The Research Technician will be expected to plan and carry out routine work in support of the project including cell culture, preparation of nuclear extracts, protein purification, cloning and mutagenesis.

You will also assist with the development of new experimental techniques, methods and systems to improve the research outcomes. Although not essential, you will ideally have a degree in a subject relevant to the research area and have experience in a similar role.  You will have expertise with relevant Office and software packages and practical experience of applying your research skills and techniques.

Please note this position has a start date of April 2020. Please refer to the job summary for further information about the specific requirements of the role. 
 
Additional information

Leicester is a leading University committed to international excellence, world-changing research and high quality, inspirational teaching. We are strongly committed to inclusivity, promoting equality and celebrating diversity among our staff. Located close to the city centre, our staff enjoy a friendly and supportive working environment, plenty of training opportunities and a wide range of excellent campus facilities.

In return for your hard work, we offer a working environment that is committed to inclusivity, through promoting equality and valuing diversity. We offer a competitive salary package with excellent pension scheme and a generous annual leave allowance. Located close to Leicester city centre, our award winning campus benefits from a wide range of cafes, a fully equipped sports centre and nursery facilities. Further information regarding our extensive range of staff benefits is available here. 
 
Informal enquiries are welcomed and should made to Prof Ian Eperon on +44 (0)116 229 7012 or eci@leicester.co.uk.