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About the role

A postdoctoral researcher position is available for 3 years with a possible two year extension on a multi-disciplinary BBSRC-funded sLOLA grant entitled, ‘How do RNA-binding proteins control splice site selection?’.

RNA/molecular biology/single molecule microscopy

One of the biggest challenges in molecular biology is presented by the selection of sites for RNA splicing. We cannot overstate its importance or apparent complexity. We have recently developed a multi-disciplinary approach based on single molecule methods and chemical biology that will enable us to meet this challenge. This £4m grant brings together experts in RNA splicing, single molecule spectroscopy, chemical biology, structural biology and nano-patterning of surfaces and will support 7 postdoctoral researchers (4 in Leicester, 2 in Strathclyde and 1 in Glasgow) who will use and develop methods involving single molecule colocalization, FRET and scattering, chemical synthesis, NMR, molecular biology and novel surface modifications.

About you

The appointee’s research will involve studies on the processes controlling clinically-relevant switches in splicing using RNA biochemistry, single molecule microscopy, cloning and expression in mammalian cells, analysis of expression, cross-linking, proximity labelling and other methods. In addition, the post-holders will contribute to the development of the laboratories and co-supervision of undergraduate and postgraduate students.

Candidates will have a high quality first degree and PhD in a relevant subject and will be able to demonstrate a high level of activity and engagement in their previous research and relevant research expertise.

Additional information

Informal enquiries are welcomed and should made to Prof Ian Eperon on +44 (0)116 229 7012 or eci@leicester.co.uk.

Leicester is a leading University committed to international excellence, world-changing research and high quality, inspirational teaching. We are strongly committed to inclusivity, promoting equality and celebrating diversity among our staff and students. You will develop your career in a supportive and collaborative academic environment in one of the world’s leading research-intensive universities; elite in the excellence of our research, yet distinctive for the genuine synergy between our research and teaching.

In return for your hard work, we offer a competitive salary package with excellent pension scheme and a generous annual leave allowance. Located close to Leicester city centre, our award winning campus benefits from a wide range of cafes, a fully equipped sports centre and nursery facilities. Further information regarding our extensive range of staff benefits is available here.