This post, funded by the Wellcome Trust, is for a skilled postdoctoral researcher to join an established, successful research team. The aim of our research is to explore the structure and function of large histone deacetylase containing repression complexes.
The project involves studying the interaction of the repressive transcription factor BACH1 with class I HDAC complexes containing HDAC1, HDAC1 and HDAC3. The project will also investigate the role of heme binding on the interaction.
The Schwabe group is looking for a Research Associate with experience of using a wide range of biochemical and biophysical techniques. These include the expression and purification of protein complexes from E. coli and expression and purification of large multi-protein protein complexes from mammalian cells. Experience of Cryo-EM, NMR and Crystallography is essential. Electromobility Shift assays and Fluorescence Correlation Spectroscopy will be used to monitor DNA binding.
The group is part of the Leicester Institute of Structural and Chemical Biology (LISCB), one of five flagship research institutes recently established by the University of Leicester, UK. We have excellent access to state-of-the-art structural biology technologies including an in house Krios cryo-EM microscope equipped with Falcon 3EC and GATAN K3 detector as well as the Diamond and ESRF Synchrotrons.