About the role

We are seeking a highly motivated Post-Doctoral Research Associate to work on a new BBSRC-funded project 'Molecular grammar of a cell-type specific alternative splicing regulator' as part of an interdisciplinary team based at the Department of Biochemistry, University of Cambridge (Professors Chris Smith and Dr Katherine Stott) and the College of Life Sciences, University of Leicester (Professors Ian Eperon, Cyril Dominguez and Andrew Hudson). The project builds upon the discovery by the Cambridge team of the RNA binding protein RBPMS as a regulator of smooth muscle cell specific splicing and the finding that recombinant RBPMS can confer cell specific splicing in vitro, and self-assemble into phase separated states. The project will investigate the molecular and biophysical basis of splicing regulation using an array of state of the art biophysical, structural, molecular and chemical biology techniques, including single molecule analyses of splicing complexes as pioneered by the Leicester team.

The post-holder will work within the group of Professor Ian Eperon (Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology) in close collaboration with Professor Andrew Hudson (School of Chemistry) and Dr C. Dominguez (MCB and LISCB).

The work will involve designing and building a TIRF microscope with annular excitation pathways, creating a user interface for the microscope, single molecule TIRF microscopy and analysis of RNA-protein interactions by techniques including FRET.

Length of advert - 2 weeks

About you

You will hold a high‑quality first degree and PhD in Biochemistry or a related subject (or near completion), with a strong track record of research activity demonstrated through publications and presentations in leading scientific forums. You will bring hands‑on experience in single‑molecule microscopy, skills in optics or photonics, and proven ability in developing software for imaging analysis, particularly using Python. Your ability to work independently while contributing to a collaborative research team will be essential, as will excellent communication skills and a commitment to continuous professional development.

You will thrive in an environment that values curiosity, originality and teamwork, and you will be motivated by the opportunity to lead experimental innovation within a world‑class research programme. The University of Leicester is committed to equity, diversity and inclusion, and to fostering a research culture where diverse perspectives are welcomed and all staff can contribute meaningfully to our collective ambition to create positive impact

Additional information

Informal enquiries are welcome and should be made to Professor Ian Eperon on [email protected]

Applications for job share will be considered.

As part of the University’s ongoing commitment to professional development, this role will also be considered on a seconded basis for existing staff members. Please ensure this is discussed with your line manager prior to applying. More information regarding secondments can be found here

The University of Leicester has been changing the world, and changing people’s lives, for 100 years. When you join us, you’ll become part of a community of Citizens of Change, which includes not only our staff and our current students but also thousands of Leicester graduates around the world.

As a diverse and forward-thinking employer, we embed the principles of equity, diversity and inclusion into everything we do. That includes not just our core missions of teaching and research, but also our support for staff, students and our local community through our values of Inspiring, Impactful and Inclusive through our values of Inspiring, Impactful and Inclusive.

We’re committed to the wellbeing of all our staff and to the sustainability of our environment, on our campus and beyond. We offer a competitive salary package, excellent pension scheme and a generous annual leave allowance, along with opportunities to develop your career in a supportive and collaborative environment.

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Post Doctoral Research Associate

About the role

About you

Additional information

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