About the role

This research is a collaborative project between the Schwabe and Markaki groups and funded by the BBSRC to study the structure and function of proteins and protein complexes that are involved in the inactivation of the X-chromosome.

The Schwabe group is looking for a Research Assistant with experience of using a wide range of biochemical and biophysical techniques. These include the expression & purification of proteins from E. coli, expression & purification of large multi-protein protein complexes from mammalian cells, Cryo-Electron Microscopy, NMR and crystallography.

The group is part of the Leicester Institute of Structural and Chemical Biology (LISCB), one of five flagship research institutes recently established by the University of Leicester, UK. We have excellent access to state-of-the-art structural biology technologies including an in house Krios cryo-EM microscope equipped with Falcon 3EC and GATAN K3 detector as well as the Diamond and ESRF Synchrotrons.

About you

The successful candidate will have an honours degree and relevant experience in Structural Biology. This role requires experience of expression of large multi-protein complexes in mammalian cells, expression of histone proteins, techniques involved in chromatin preparation and analysis of protein structure using cryo-EM, NMR and crystallography. Interest and enthusiasm for working in the field of Structural Biology is essential. You will have practical experience and knowledge of applying your research skills, an ability to work both independently and as part of a team, and an ability to prioritise tasks within agreed work schedules.

Additional information

Informal enquiries are welcome and should be made to Professor John Schwabe on [email protected]

As part of the University’s ongoing commitment to professional development, this role will also be considered on a seconded basis for existing staff members. Please ensure this is discussed with your line manager prior to applying. More information regarding secondments can be found here

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