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About the role

There is a unique opportunity to join an established translational group led by Prof. Gavin Murphy to study molecular mechanisms behind organ injury after heart surgery. The post is open to an enthusiastic individual with a strong background in bioinformatics who would like to learn modern wet-lab techniques.

This British Heart Foundation-funded project will investigate retrograde, mito-nuclear signalling and epigenetic changes driven by obesity that protect against organ injury after ischaemia-reperfusion in procedures like cardiac surgery. The successful candidate will use RNA sequencing, single-cell sequencing, ChIP-seq, proteomics and metabolomics to generate data from tissues obtained from patients enrolled in two clinical trials Val-CARD and PRE-OP ENERGY. Close collaboration with Nucleus genomics sequencing and van Geest proteomics facilities will ensure the highest standards, and collaboration with Prof. Eugene Zhang from the Informatics department will help us develop a machine-learning methodology for the analysis of multilevel omics data.

The job offers a stimulating and supportive working environment of a multidisciplinary team involving biologists, statisticians, bioinformaticians and clinicians. We are based in the Department of Cardiovascular Sciences, which is internationally recognised for its high-impact research into a broad spectrum of cardiovascular diseases. The successful candidate will learn cutting-edge wet-lab multiomics techniques and dry-lab advanced bioinformatics and machine learning. We also offer support in further career development.

About you
We are seeking a candidate with a PhD in biology or bioinformatics with a track record of analysing omics data. The post would particularly benefit an individual looking to develop their independent career and support would be offered toward a fellowship application towards the end of the funding period.
Additional information

Informal enquiries are welcome and can be made to Dr. Marcin Wozniak (mw299@le.ac.uk). 

Leicester is a leading University committed to international excellence, world-changing research and high quality, inspirational teaching. We are strongly committed to inclusivity, promoting equality and celebrating diversity among our staff and students.

The Department of Cardiovascular Sciences is committed to sustaining a progressive, equality driven environment in which all our staff can thrive.  We believe this can be accomplished through attracting, developing, and retaining a diverse range of staff from many different backgrounds. In supporting our employees to achieve a balance between work and personal lives, we consider proposals for flexible working as well as job share arrangements. 

In return for your hard work, we offer a working environment that is committed to inclusivity, through promoting equality and valuing diversity. We offer a competitive salary package with excellent pension scheme and a generous annual leave allowance. Located close to Leicester city centre, our award winning campus benefits from a wide range of cafes, a fully equipped sports centre and nursery facilities. Further information regarding our extensive range of staff benefits is available here.